BOF 82

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BOF 82
Aetiologies of rheumatoid arthritis (RA) all are true, except:
1-HLA DR3 is the major susceptibility haplotype in most ethnic groups
2-concordance rate in monozygotic twins is 15% versus 3% in dizygotic twins
3-female gender per se is considered to be a risk factor and this susceptibility is increased post-partum and by breast feeding
4-cigarette smoking is a risk factor for RA and for positivity for rheumatoid factor in non-RA subjects
5-up to 50% of genetic contribution to susceptibility is due to genes in the HLA region

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