BOF: 4
A 48-year female presents with a rash, joint pains and
weakness of her right lower limb.
On examination she has palpable purpura, no definite
arthritis but examination of the lower limb reveals common peroneal nerve
palsy.
Investigations reveal:
Haematology normocytic normochromic anaemia
White cell count normal
ESR 120 mm in 1st hour
Rheumatoid factor strongly positive
ANA negative
ANCA negative
C3 90 mg /dL (65-190)
C 45 mg/dL (15-50)
Echocardiogram normal
In this patient the likely diagnosis is:
a)
Rheumatoid arthritis
b)
Systemic lupus erythematosus
c)
Churg-Strauss syndrome
d)
Subacute infective endocarditis
e)
Mixed cryoglobulinaemia