Best of Five 3.56

 

   

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BOF: 3.56

 

A 30-year-old male presents with a history of feeling tired and passing dark urine. Five days prior to presentation his general practitioner had treated him with co-trimoxazole, as he had been complaining of a sore throat.

Investigations reveal:

Haemoglobin 8.4 g/dL (11.5 – 16.5 g/d)

Serum total bilirubin 107 μmol/L (1 – 22 μmol/L)

The blood film shows multiple bite cells

The most likely cause of this patient’s present problem is:

 

a)      Paroxysmal cold haemoglobinuria

 

b)      Autoimmune haemolytic anaemia

 

c)      Glucose-6-phosphate dehydrogenase deficiency

 

d)      Cold agglutinin disease

 

e)      Paroxysmal nocturnal haemoglobinuria

 

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