If you find the material on this website useful, you will find that the two books ACES for PACES and KEYS to SUCCESS in Medicine complement the material on these sites and will enhance your studying and revision

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BOF: 7

Which one of the following is a recognised effect of BNP (brain natriuretic peptide, B type natriuretic peptide)?

a)   Peripheral vasoconstriction

b)   Constriction of pulmonary arteries

c)    Increased sympathetic tone

d)   Inhibition of renin angiotensin aldosterone system

e)   Decreased natriuresis

Answer :d)

BNP release

ü  Left ventricular wall stretched by volume overload

ü  Cardiac muscle cells secretes BNP precursor

ü  Precursor converted to pro BNP

ü  Pro BNP cleaved into

·         C-terminal BNP (biologically active)

·         N-terminal BNP (biologically inactive)

 

Action of natriuretic peptides

ü  Suppresses sympathetic nervous system

ü  Suppresses renin angiotensin aldosterone system

ü  Stimulates natriuresis

ü  Decreases peripheral vascular resistance

ü  Increases smooth muscle relaxation

 

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