Answer BOF 52

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BOF: 52

A 40 year old Indian male has blood tests done as part of a routine check up .

The results are as follows:

Hb 12.5 g/dL

MCV 66 fl

MCH 24 pg

MCHC 26 g/dL

WBC 6.1 x10⁹/L

Platelets 232 x10⁹/L

In this patient which one of the following tests is most likely to identify the cause of the condition?

a)      Iron studies

b)      Haemoglobin electrophoresis

c)      Colonoscopy

d)      Stools for amoebae, ova and cysts

e)      Bone marrow examination

Answer: b)

The patient is probably asymptomatic as the tests were done as part of a routine medical check up.

He has a marked microcytosis in comparison to the haemoglobin level. This should alert you to the possibility of thalassaemia.

The diagnosis would be made by haemoglobin electrophoresis, which would show an elevation of Hb A₂and Hb F

Revision Tip

Revise thalassaemia KEYS to SUCCESS in Medicine page 382-384

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