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 Answer BOF 3.28

 

   

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BOF: 3.28

You are called to see a 60-year-old female on the oncology ward. She has breast cancer with bone metastases. Her serum calcium level is 3.8 mmol/l.

Which of the following features are likely to occur in this patient?

a)      Hyporeflexia on neurological examination

b)      Prolonged QT interval on the ECG

c)      Tachycardia

d)      Tall peaked T waves

e)      Diarrhoea

Answer: a)

Hypercalcaemia may result in the following features in relation to the CNS:

Personality changes, malaise, headache, hallucinations, depression, irritability confusion, depressed sensorium, unsteady gait, proximal muscle weakness, hyporeflexia

The ECG changes that may occur are:

Shortened QT interval, bradycardia, coving of ST-T wave, widened T wave

The features in relation to the gastrointestinal system are:

Hypercalcaemia may cause paralytic ileus, with resultant abdominal cramping, constipation, anorexia, nausea, and vomiting.

Ectopic calcification may lead to features of pancreatitis, with epigastric pain and vomiting.

Increased gastric acid secretion may produce features of gastritis

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