If you find the material on this website useful, you will find that the two books ACES for PACES and KEYS to SUCCESS in Medicine complement the material on these sites and will enhance your studying and revision

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ACES for PACES

Medical Revision

Clinical Skills Blogspot

Web ydr.org.uk acesforpaces.com medicalrevision.org

BOF: 31

What is the mechanism of action of clopidrogel?

a)   Inhibitor of cyclo-oxygnease

b)   Adenosine diphosphate receptor antagonist

c)    Inhibition of adenosine uptake into platelets

d)   Glycoprotein IIb/IIIa antagonist

e)   Phosphodiesterase inhibitor

Answer: b)

 

Clopidogrel

ü  Adenosine diphosphate (ADP) receptor antagonist

ü  Competitively inhibits ADP from binding to platelet receptors

ü  Prevents ADP mediated up-regulation of glycoprotein  IIb/IIIa receptor

 

Aspirin

ü  Non-selective, irreversible inhibitor of cyclo-oxygenase

ü  Reduces production of thromboxane and prostaglandins

ü  Antithrombotic action derives from reduction in thromboxane A2

 

Dipyridamole

ü  Mechanism not fully understood

ü  Thought to act by inhibiting adenosine uptake into platelets and reducing ADP-induced aggregation

 

Abciximab

Tirofiban

ü  Glycoprotein IIb/IIIa antagonists

Revision Tip

Revise acute coronary syndrome KEYS to SUCCESS in Medicine page 148-150

 

 

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