BOF: 2.43
A 46-year-old female has been on long-term treatment for schizophrenia. She
has been referred to the medical clinic as she has put on a lot of weight and
developed diabetes mellitus. You see her at the clinic and take a detailed
drug history, as you are aware that the following drug could be responsible
for her weight gain and the development of diabetes mellitus:
a)
Chlorpromazine
b)
Haloperidol
c) Clozapine
d)
Risperidone
e) Olanzapine
Answer:
e)
The drugs used in the treatment of schizophrenia are:
Antipsychotic Drugs (Neuroleptics)
These drugs act by blocking the D1 and D2
groups of dopamine receptors.
The drugs are:
Phenothiazines
Chlorpromazine
Trifluoperazine
Fluphenazine
Butyrophenones
Haloperidol
Atypical Antipsychotics
(Block D2 less than D1)
Clozapine
Risperidone
Olanzapine (causes weight gain and increases risk of
diabetes mellitus)
Sulpiride
Quietiapine
Ziprasidone
