BOF 29
Anti-nuclear antibodies (ANA), all are true except:
1-the routine detecting test is indirect
immuno-fluorescent technique
2-the higher the titre, the greater the significance
3-the ANA is directed against one or more components
of the nucleus
4-in drug induced lupus, it is presenting up to 60% of
cases
5-the sensitivity and specificity vary widely
Answer 4
1-eg using rodent organs or human cell lines
2-like RF, low tires may be seen in healthy normal
people in a good percentage
3-hence its name
4-FALSE, 100% of cases .negative titre virtually
excludes drug induced lupus( here it is mainly anti histone H2 A and B
subtypes )
5-depends on the antigen preparation used in the test
and weather we detect IgG or IgM type .however the tests are unfortunately NOT
standardized and liaison with local labs is important
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SLE KEYS to SUCCESS in Medicine page
506-508
