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BOF 22
Causes of macrocytosis without a megaloblastic bone marrow, all are true except
1-myelodysplastic syndromes
2-aplastic anaemia
3-multiple myeloma
4-chronic myeloid leukaemia
5-fish tapeworm infestation

Answer 5
Remember: macrocytosis is very common in clinical practice but megaloblastic anaemia is uncommon and the term macrocytosis indicates an increase in the MCV but megaloblastic changes are pathological changes seen in the cells mainly in the nucleus.
Fish tapeworm infestation causes B12 deficiency and hence megaloblastic changes
Note the first 4 cause characteristic changes in the bone marrow

 

 

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